Melatonin
TI-Melatonin®: Biological effects and scientific information:
TI-Melatonin® expresses the best imaginable melatonin preparation available
on the world-market and is now available as a food additive and dietary supplement
to anybody wanting to take advantage of the extraordinary scientific observations
of Dr. Walter Pierpaoli and his co-workers. The basic experimental findings of
35 years of research, resulted in the discovery of the undeniable existence of
a programmed "Aging Clock" in the pineal gland complex of the brain.
We have investigated the possible mechanisms and also the molecules which presumably
cooperate and synergize with melatonin in the regulation and re-synchronization
of the fundamental immunological and hormonal functions, (which are normally lost
or deranged in the course of aging). In recent studies and long-term experiments
with old rodents it has been observed that zinc can completely correct aging-dependent
immuno-depression and several other hormonal and metabolic alterations typical
of aging. It has been found that the low zinc levels in aging animals can be restored
to normal values with nocturnal administration of melatonin or transplantation
of the pineal gland from young animals into older animals6-9. Zinc is an essential
component of more than 200 enzymes and one of the most relevant trace elements
in the body8,9. It is therefore clear that additional zinc must be supplemented
daily to the body of an aging organism with a low zinc balance, in-order that
melatonin can better exert its anti-aging activities on the entire neuroendocrine
and immune systems! This important and novel scientific observation of the powerful
anti-aging and immuno-enhancing activity of the combination of zinc and melatonin
has now resulted into the development of TI-Melatonin®. Furthermore, selenium
is a fundamental trace element of the body and possesses powerful anti-cancer
effects. But modern agriculture and alimentary habits have dramatically decreased
the daily input of selenium from the diet. Selenium is essential for the enzymatic
reaction responsible for the synthesis of glutathione, a powerful physiological
molecule which constantly protects the body from oxidative damage. A lack of selenium
will thus result in a loss of the detoxification capacity of the body, immuno-depression
and onset of degenerative diseases and cancer10. This is the reason why TI-Melatonin®
combines, (in a unique synergistic combination), the three fundamental anti-aging
molecules of melatonin, zinc and selenium. Whilst melatonin plays the master role
for reactivation and restoration of its natural night peak to juvenile levels,
(this resulting into normalization of all measurable immunological and endocrine
functions in the course of aging), the positive age-postponing, metabolic and
immunological effects of TI-Melatonin® can be measured easily by anybody with
a normal periodic check-up! These restoring metabolic changes will become progressively
more visible and remarkable over the course of years, after initiation of the
treatment with TI-Melatonin®. Further studies are now in progress and they
will allow us to progressively add more elements suitable to further improve and
accelerate the rejuvenizing effects of nocturnal melatonin. But the "programme
of aging" can be slowed down now to a more acceptable rate with regular nocturnal
use of TI-Melatonin®.
TI-Melatonin®:
Composition of active components in each tablet:
Melatonin (N-acetyl-5-methoxytryptamine), 3mg, synthetic, certified purity: (99.9
% (HPLC), Zinc-orotate x 2H2O, 50mg corresponding to 8.7mg zinc. Selenium, 50mcg,
from sodium selenite pentahydrate. TI-Melatonin® is produced in Switzerland
in compliance with the severe international rules of Good Manufacturing Practise
(GMP) and under licence of Swiss Health Authorities. Contraindications
and general suggestions:
TI-Melatonin® should not be given to healthy
children, pregnant women and lactating mothers unless specifically prescribed
by a physician. There is no evidence that TI-Melatonin® could adversely influence
the effects and activity of estrogens. On the contrary, melatonin increases the
density of estrogen receptors in sensitive target tissues (mammary gland, womb,
ovaries, etc.) and greatly improves their actions. There are no contraindications
for dietary supplements containing melatonin, zinc and selenium. No ascertained,
life-threatening, acute or moderate, short- or long-term side-effects have been
scientifically demonstrated or reported. Melatonin must be taken late in the evening
at bedtime in order to mimic and restore the physiological night peak, which normally
declines progressively during the course of aging. As mentioned in the literature
reported above, the progressive abrogation of melatonin night-cyclicity during
aging is considered to be a basic signal expressing the extinction of the most
fundamental regulatory system in the body. This brain "clock" is genetically
and evolutionary linked to the sun, the planetary system and the obvious dependence
of our health from daily and nocturnal, rhythmic cyclicity. Every person expresses
their own genetically inherited nocturnal peak of melatonin, with very large individual
variability. However, in the majority of the population, the night elevation of
melatonin declines and most of us become "flat" after 80 years of age.
This is a basic aging message from the "clock"11. The dosage of melatonin
is still rather empirical and based on animal and human studies. The blood night
level generated by 3mg by far exceeds the normal night levels of healthy young
persons. However, melatonin is rapidly metabolized and excreted by the kidneys
with no consequences. Use of beta-blockers in the evening may abrogate the night
peak of melatonin. If they must be taken, it may be necessary to take them in
the morning or to increase the dosage of melatonin. Circadian, night melatonin
seems to produce a resynchronization of the entire neuroendocrine system and will
certainly improve metabolic and hormonal functions, including blood pressure,
cholesterol levels, thyroid, gonadal and adrenal functions. These effects can
be easily evaluated with a routine check-up. Melatonin will counteract the negative
side-effects of cortico-steroids and of di-stressful agents, thus protecting the
immune system. Melatonin does not induce sleep but facilitates its onset and produces
a sleep pattern which is typical of children or young persons. It greatly improves
the quality of sleep and its restoring physical and psychological effects, with
a clear improvement of morning mood and body muscle strength. Melatonin is not
a drug and it is not itself a cure for any disease! Melatonin is ubiquitous in
nature, cells, plants, animals, tissues and any living organism. Milk, vegetables,
cereals, rice, meat, etc., contain variable amounts of melatonin. Synthetic melatonin
could be theoretically replaced by alimentary melatonin in the daily food, but
its replacement would be problematic and difficult to achieve for everybody. Melatonin
produced by the pineal gland seems to be responsible for the night peak, while
melatonin produced by the gut and the retina does not seem to affect the nocturnal
levels. It is thus evident that the night peak of melatonin initiates a sequence
of positive effects with a cascade of events which maintain the body systems synchronized
with the physiological cyclicity of hormones and cells. This night "signal"
is essential for the maintenance of immunity and the "surveillance"
against the onset of tumors. Therefore melatonin is a fundamental element for
prevention of aging-related diseases, including cancer, autoimmune and cardiovascular
diseases. Melatonin cannot be considered a classical "hormone," although
it is so-named. It does not possess any of the qualities of the classical hormones
like growth hormone, cortisol, estrogens, thyroid hormones etc. It is rather a
chemical mediator whose mechanism is still unknown. It modulates and controls
the synthesis and secretion of all hormones within a circadian and seasonal periodicity
and variability. It has been given at a huge dosage of grams daily for prolonged
periods, and to 1500 women at the daily dosage of 300mg for years with no observed
late side-effects and consequences. The administration of melatonin to restore
the physiological adaptation of the body to circadian and seasonal periodicity
is only the beginning of a new medicine based on the concept that nobody can escape
the established laws of Nature within the solar-planetary system, in which man
developed as a mammalian species. We must be able to restore and correct the derangements
of this adaptation system and maintain it in its original juvenile conditions.
These metabolic conditions can be perfectly measured and maintained under balance,
not with a cumbersome and complex hormonal supplementation (e.g. testosterone,
growth hormone, pregnenolone, etc.), but with a correction of the central regulatory
system located in the "pineal complex" (pineal gland and the many anatomical
and functional connections in the brain and the neuroendocrine-immune systems).
TI-Melatonin® is perfectly suitable to re-synchronize all neuroendocrine functions.
TI-Melatonin® contains basic elements which will synergize in order to obtain
more rapid effects and to compensate the loss of fundamental minerals, due to
a wrong diet or to aging. The beneficial effects of melatonin in the normalization
of zinc levels have been scientifically proven and constitute a basic tool for
maintenance of hormonal and immune functions and to restore these functions during
aging. Common
agents which antagonize synthesis and secretion of melatonin:
Alcohol,
cortico-steroids, beta-blockers (especially in the evening), caffeine, nicotine
and many chemical substances with pharmacological activity can antagonize the
synthesis and secretion of Melatonin. But melatonin does not itself antagonize
the activity of any drug and can be used in combination with any medical drug
and pharmaceutical specialty. Nocturnal melatonin will in-fact improve the effectiveness
and activity of drugs as a consequence of its synchronizing properties on the
entire neuroendocrine and immune systems. TI-Melatonin®:
Suggested daily dosages as a dietary supplement:
Between 40 and 50 years
of age: 1.5mg to 3mg at bedtime (peremptorily at the same hour, with half an hour
tolerance). After 50 years until 75 years of age: 3mg at bedtime- as above. From
75 years of age: 3-6mg at bedtime- as above. Although not mandatory, it is indicated
to take TI-Melatonin® for 5 months in summer (May-June-July-August-September)
and for 5 months in winter (November-December-January-February-March). TI-Melatonin®
can be safely taken without intervals after 50 years of age, in the presence of
chronic, degenerative diseases and cancer, or as a protective agent under stressful
conditions (night-work, exposition to poisons and noxious agents, time-zone travel
etc.). It is strongly recommended to take TI-Melatonin® for periods of weeks
before and after surgical interventions to ameliorate general conditions (mood,
immunity, etc.) and to accelerate immunological reconstitution, wound healing,
tissue regeneration and recovery from anesthesia toxicity after the operation.
For jet-lag we suggest taking 3mg of TI-Melatonin® for four to five days at
10-11 PM, local time, on arrival at the place of destination and to repeat the
same procedure after returning to the original place of departure.
Keep
this and all other medicines safely out of the reach of children. 
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